You shouldn't have any problem with having a Reverse Mortgage and running a business out of your personal residence.However, there are limits on Reverse Mortgages in multi unit buildings and mixed use property (property that is both commercial and residential), but it doesn't sound like this applies to you.You can learn more from a Reverse Mortgage lender. You can find a prequalified lender here: https://www.newretirement.com/Services/Reverse_Mortgage_Advice.aspx?ReverseMortgageAdviceTab.DateOfBirth=1/1/1943&ReverseMortgageAdviceTab.HouseValue=150000&ReverseMortgageAdviceTab.MortgageBalance=50000